Treatment Guidelines for Implantation of Cardiac Pacemakers and Antiarrhythmia Devices

The American College of Cardiology/American Heart Association Task Force on Practice Guidelines has a published set of guidelines on when and how to use pacemakers and other antiarrythmia devices. The guidelines classify various treatments based on whether the benefit outways the risk of treatment.

A class I treatment the benefits greatly outweigh the risks. In a Class II treatment the benefits outweigh the risks by a smaller margin. In a class III treatment the benefits and risks are close, and in a class IV treatment, the risks outweigh the benefits. Here is how the task force viewed various treatments for arrhythmias.

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Guidelines for use of Endomyocardial Biopsy


If you are wondering what the procedure and guidelines for the role of endomyocardial biopsy in the management of cardiovascular disease, the National Guideline Clearinghouse of the U.S. Department of Health and Human Services has provided a thorough summary. Below is a brief excerpt from the guideline:

To define the current role of EMB in the management of cardiovascular disease, a multidisciplinary group of experts in cardiomyopathies and cardiovascular pathology was convened by the American Heart Association (AHA), the American College of Cardiology (ACC), and the European Society of Cardiology (ESC). The present Writing Group was charged with reviewing the published literature on the role of EMB in cardiovascular diseases, summarizing this information, and making useful recommendations for clinical practice with classifications of recommendations and levels of evidence.

The Writing Group identified 14 clinical scenarios in which the incremental diagnostic, prognostic, and therapeutic value of EMB could be estimated and compared with the procedural risks.

Classification of Recommendations

Class I: Conditions for which there is evidence or there is general agreement that a given procedure is beneficial, useful, and effective

Endomyocardial biopsy (EMB) should be performed in the setting of unexplained, new-onset heart failure of <2 weeks' duration associated with a normal-sized or dilated left ventricle in addition to hemodynamic compromise. Class of Recommendation I, Level of Evidence B.

EMB should be performed in the setting of unexplained new-onset heart failure of 2 weeks' to 3 months' duration associated with a dilated left ventricle and new ventricular arrhythmias, Mobitz type II second- or third-degree atrioventricular (AV) heart block, or failure to respond to usual care within 1 to 2 weeks. Class of Recommendation I, Level of Evidence B.

EMB is reasonable in the clinical setting of unexplained heart failure of >3 months’ duration associated with a dilated left ventricle and new ventricular arrhythmias, Mobitz type II second- or third-degree AV heart block, or failure to respond to usual care within 1 to 2 weeks. Class of Recommendation IIa, Level of Evidence C.

EMB is reasonable in the setting of unexplained heart failure associated with a dilated cardiomyopathy (DCM) of any duration that is associated with suspected allergic reaction in addition to eosinophilia. Class of Recommendation IIa, Level of Evidence C.

EMB is reasonable in the setting of unexplained heart failure associated with suspected anthracycline cardiomyopathy. Class of Recommendation IIa, Level of Evidence C.

EMB is reasonable in the setting of heart failure associated with unexplained restrictive cardiomyopathy. Class of Recommendation IIa, Level of Evidence C.

EMB is reasonable in the setting of suspected cardiac tumors, with the exception of typical myxomas. Class of Recommendation IIa, Level of Evidence C.

EMB is reasonable in the setting of unexplained cardiomyopathy in children. Class of Recommendation IIa, Level of Evidence C.

EMB may be considered in the setting of unexplained, new-onset heart failure of 2 weeks’ to 3 months’ duration associated with a dilated left ventricle, without new ventricular arrhythmias or Mobitz type II second- or third-degree AV heart block, that responds to usual care within 1 to 2 weeks. Class of Recommendation IIb, Level of Evidence B.

EMB may be considered in the setting of unexplained heart failure of >3 months’ duration associated with a dilated left ventricle, without new ventricular arrhythmias or Mobitz type II second- or third-degree AV heart block, that responds to usual care within 1 to 2 weeks. Class of Recommendation IIb, Level of Evidence C.

EMB may be considered in the setting of heart failure associated with unexplained hypertrophic cardiomyopathy (HCM). Class of Recommendation IIb, Level of Evidence C.

EMB may be considered in the setting of suspected arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C). Class of Recommendation IIb, Level of Evidence C.

EMB may be considered in the setting of unexplained ventricular arrhythmias. Class of Recommendation IIb, Level of Evidence C.

EMB should not be performed in the setting of unexplained atrial fibrillation. Class of Recommendation III, Level of Evidence C.

For the complete guideline, please visit the website here.

Guidelines for Management of Congenital Heart Disease

If you are wondering what the procedure and guidelines for Management of Congenital Heart Disease diagnostic, the National Guideline Clearinghouse of the U.S. Department of Health and Human Services has provided a thorough summary. Below is a brief excerpt from the guideline:

Evaluation of the Unoperated Patient

  1. Clinical examination for signs of atrial septal defect (ASD)
  2. Imaging studies (e.g., electrocardiogram, chest x-ray, echocardiography, magnetic resonance imaging)
  3. Maximal exercise testing
  4. Cardiac catheterization

Management Strategies

Medical Therapy

  1. Cardioversion after appropriate anticoagulation
  2. Rate control and anticoagulation

Interventional and Surgical Therapy

  1. Percutaneous or surgical closure of the ASD
  2. Concomitant maze procedure for intermittent or chronic atrial tachyarrhythmias in adults

Postintervention Follow-Up

  1. Evaluation for postpericardiotomy syndrome with tamponade
  2. Annual clinical follow-up in defined patient subgroups
  3. Evaluation for possible device migration, erosion, or other complications

Reproduction

Discouragement of pregnancy in patients with ASD and severe pulmonary artery hypertension (PAH) (Eisenmenger syndrome)

For the complete guideline, please visit the website here.

Guidelines for Conorary and Atherosclerotic Vascular Disease Diagnostic

If you are wondering what the procedure and guidelines for coronary and other atherosclerotic vascular disease diagnostic, the National Guideline Clearinghouse of the U.S. Department of Health and Human Services has provided a thorough summary. Below is a brief excerpt from the guideline:

Interventions and Practices Considered

  1. Advice and assistance in smoking cessation
  2. Avoidance of second-hand smoke
  3. Blood pressure control
    • Lifestyle modification
    • Drug therapy (beta-blockers, thiazides, angiotensin-converting enzyme [ACE] inhibitors)
  4. Lipid management
    • Diet therapy
    • Addition of plant sterol/stanol
    • Physical activity and weight management
    • Consumption of omega-3 fatty acids
    • Assessment of fasting lipid profile
    • Lipid-lowering drug therapy
  5. Encouragement and counseling on physical activity
  6. Weight management
    • Assessment of body mass index and waist circumference
    • Encouragement of weight maintenance/reduction
    • Weight loss therapy
  7. Diabetes management
    • Lifestyle and pharmacotherapy
    • Risk factor modification
  8. Use of antiplatelet agents (aspirin, clopidogrel) and anticoagulants (warfarin)
  9. Use of ACE inhibitors, angiotensin receptor blockers, and aldosterone blockers
  10. Use of beta-blockers
  11. Influenza vaccination

For a complete guideline, please visit the website.

Guidelines for Global Cardiovascular Risk Assessment

If you are wondering what the procedure and guidelines for global cardiovascular risk assessment, the National Guideline Clearinghouse of the U.S. Department of Health and Human Services has provided a thorough summary. Below is a brief excerpt from the guideline:

Description of the Methods Used to Analyze the Evidence

At the first meeting, members of the Writing Committee were given assignments to provide descriptions and analyses of coronary artery calcium (CAC) measurement for identifying and modifying coronary event risk in the asymptomatic patient, for modifying the clinical care and outcomes of symptomatic patients suspected of having coronary artery disease (CAD), and for understanding the role of CAC measurement in selected patient subgroups.

Considerable discussion among the group focused on the best and most proper way to assess clinical appropriateness of tests such as CAC measurement since there have been no clinical trials to evaluate the impact of CAC testing on clinical outcomes in either symptomatic or asymptomatic patients. The Writing Committee agreed uniformly that the ideal assessment of cardiac tests would require clinical trials that utilize important patient outcomes such as improving the quality or quantity of a patient’s life. However, recognizing that this standard is not available for CAC measurement, the Committee considered other standards of evidence in reaching a consensus opinion.

Two committee members evaluated the quality of each included report with the results of this analysis being included in Table 2 in the original guideline document. The quality assessment criteria included: 1) documentation of prospective data collection; 2) inclusion of self-referred patient series or from a population sample; 3) reporting of coronary heart disease (CHD) events; 4) reporting of outcome data by gender and ethnicity; 5) sample size greater than 1000 individuals; 6) avoiding potential for limited challenge (i.e., an inclusion of very low to very high-risk patients resulting in a wide spread in the outcome results) by not reporting data within strata of clinical risk; 7) reporting measured versus historical or self-reported risk factor data; and 8.) reporting univariable and multivariable prognostic models (i.e., ascertaining the incremental value of CAC scores). A review of the highlighted reports reveals that all studies identified for inclusion were of at least moderate-high quality.

For the complete guideline, please visit the website.

Guidelines for Management of Ventricular Arrhythmias

If you are wondering what the procedure and guidelines for management of patients with ventricular arrhythmias, the National Guideline Clearinghouse of the U.S. Department of Health and Human Services has provided a thorough summary. Below is a brief excerpt from the guideline:

Diagnosis/Evaluation

  1. History and physical examination
  2. Resting electrocardiogram (ECG)
  3. Exercise testing
  4. Ambulatory electrocardiography
  5. Electrocardiographic techniques and measurements (T wave alternans, signal-averaged electrocardiogram (SAECG), heart rate variability (HRV), baroflex sensitivity and heart rate turbulence)
  6. Electrophysiological testing
  7. Left ventricular function and imaging
    • Echocardiograph
    • Exercise testing with an imaging modality (echocardiography or nuclear perfusion [single-photon emission computed tomography (SPECT)])
    • Cardiac magnetic resonance imaging
    • Cardiac computed tomography
    • Radionuclide angiography
    • Coronary angiography

Management/Treatment

  1. Cardiopulmonary resuscitation
  2. Automated external defibrillation
  3. Management of causes and factors contributing to cardiac arrest (electrolyte disturbances, mechanical factors, volume depletion)
  4. Direct current cardioversion
  5. Transvenous catheter placement
  6. Pharmacologic treatment
    • Antiarrhythmic agents (e.g. amiodarone, procainamide, lidocaine, sotalol, quinidine, mexiletine
    • Isoproterenol
    • Calcium channel blockers
    • Potassium and magnesium salts
    • Antidigitalis antibodies
  7. Acute and long term pacing
  8. Overdrive pacing
  9. Spinal cord modulation
  10. Left cardiac sympathetic denervation
  11. Coronary revascularization
  12. Implantation of an implantable cardioverter defibrillator (ICD)
  13. Adjunct treatments for ICD (catheter ablation, surgical resection, pharmacological therapy)
  14. Lifestyle modification
  15. Management of comorbid conditions
  16. Ventricular arrhythmias and sudden cardiac death related to specific populations
    • Athletes
    • Gender and pregnancy
    • Elderly patients
    • Pediatric patients
    • Patients with ICDs
    • Drug-induced arrhythmias

For the rest complete guideline, please visit the website.

Guidelines for Perioperative Cardiovascular Evaluation

If you are wondering what the procedure and guidelines are for perioperative cardiovascular evaluation and care for noncardiac surgery, the National Guideline Clearinghouse of the U.S. Department of Health and Human Services has provided a thorough summary. Below is a brief excerpt from the guideline:

Risk Assessment

  1. Clinical history
  2. Physical examination
  3. Assessment of comorbid disease (pulmonary disease, diabetes mellitus, renal impairment, hematologic disorders)
  4. Ancillary studies, as needed (e.g., laboratory evaluation, chest x-ray, standard electrocardiogram [ECG])
  5. Stepwise approach to perioperative cardiac assessment (clinical risk factors, prior coronary history and treatment, functional capacity, and surgery-specific risk)
  6. Supplemental preoperative evaluation:
    • Resting left ventricular function
    • 12-lead ECG
    • Exercise or pharmacological stress testing
    • Myocardial perfusion imaging
    • Dobutamine stress echocardiography
    • Ambulatory ECG monitoring
    • Coronary angiography

Management

  1. Perioperative therapy
    • Surgical coronary revascularization: preoperative coronary artery bypass grafting (CABG); percutaneous coronary intervention with or without stents (either bare metal or drug-eluting, with or without post-stent pharmacologic therapy [aspirin, clopidogrel]); percutaneous transluminal coronary angioplasty (PTCA)
    • Pharmacologic management: beta-blocker, alpha-2 agonist, and statin therapy; calcium channel blockers (no recommendation)
  2. Management of specific cardiovascular conditions
  3. Anesthetic considerations and intraoperative management
    • Anesthetic technique and agent
    • Perioperative pain management
    • Intraoperative nitroglycerin
    • Transesophageal echocardiography
    • Maintenance of body temperature
    • Intra-aortic balloon counterpulsation devices
    • Control of blood glucose concentration
  4. Perioperative surveillance
    • Pulmonary artery catheters
    • ST-segment monitoring
    • Surveillance for perioperative myocardial infarction (MI)
    • Management of postoperative arrhythmias and conduction disorders
  5. Postoperative and long-term management
    • Surveillance and treatment of MI
    • Cardiovascular medical therapy

For more information, please visit the website.

Guideline for Peripheral Arterial Disease

If you are wondering what the procedure and guidelines are for peripheral arterial disease, the National Guideline Clearinghouse of the U.S. Department of Health and Human Services has provided a thorough summary. Below is a brief excerpt from the guideline:

Diagnosis/Evaluation

  1. Medical history and review of symptoms (ROS)
  2. Diagnostic methods
    • Ankle-brachial index (ABI) and toe-brachial index
    • Segmental pressure examination
    • Pulse volume recoding
    • Continuous-wave Doppler ultrasound
    • Duplex ultrasound
    • Treadmill exercise testing with and without ankle-brachial index assessments and 6-minute walk test
    • Computed tomographic angiography (CTA)
    • Magnetic resonance angiography (MRA)
    • Contrast angiography

Management/Treatment/Prevention

  1. Cardiovascular risk reduction
    • Lipid-lowering drugs (statins, fibric acid derivatives)
    • Antihypertensive drugs (beta-blockers, angiotensin-converting enzyme [ACE] inhibitors)
    • Diabetes management (foot inspection, skin cleansing, glucose control)
    • Smoking cessation (behavioral therapy, nicotine replacement therapy, bupropion)
    • Antiplatelet and antithrombotic drugs
    • Note: The following drugs were considered but not recommended: homocysteine-lowering drugs, such as folic acid, vitamin B12
  2. Treatment of claudication
    • Supervised exercise programs
    • Pharmacological treatment (cilostazol, pentoxifylline)
    • Note: The following agents were considered but not recommended: L-arginine, propionyl-L-carnitine, ginkgo biloba, oral prostaglandins, vitamin E, chelation
    • Endovascular treatment (e.g., stenting, lasers, atherectomy, percutaneous transluminal angioplasty [PTA], thermal angioplasty)
    • Surgery (inflow and outflow procedures)
  3. Treatment for limb salvage (critical limb ischemia [CLI])
    • Parenteral prostaglandins (limited efficacy)
    • Angiogenic growth factors (considered but not recommended outside of clinical trials)
    • Endovascular treatment
    • Thrombolysis
    • Surgery
  4. Prevention: vascular ROS and prompt use of the ABI test, comprehensive pulse examination, feet inspection, and review of family history of abdominal aortic aneurysm for patients at risk for lower extremity peripheral arterial disease

For the complete guideline, please visit the website.

Guidelines for Patients with Valvular Heart Disease

If you are wondering what the procedure and guidelines are for patients valvular heart disease, the National Guideline Clearinghouse of the U.S. Department of Health and Human Services has provided a thorough summary. Below is a brief excerpt from the guideline:

General Interventions for Evaluation of Valvular Heart Diseases

  1. Echocardiography (imaging, spectral, and color Doppler): transesophageal, transthoracic
  2. Electrocardiography
  3. Chest X-ray
  4. Cardiac catheterization
  5. Exercise testing
  6. Radionuclide angiography
  7. Intraoperative transesophageal echocardiography

Interventions for Specific Valvular Diseases

Aortic Stenosis

  1. Aortic valve replacement
  2. Aortic balloon valvotomy

Aortic Regurgitation

  1. Cardiac catheterization with aortic root angiography
  2. Vasodilator therapy
  3. Aortic valve replacement
  4. Repair of thoracic aorta in patients with bicuspid aortic valves

Bicuspid Aortic Valve with Dilated Ascending Aorta

  1. Serial evaluation by echocardiography, cardiac magnetic resonance imaging, or computed tomography
  2. Surgery to repair the aortic root or replace the ascending aorta
  3. Beta-adrenergic drug therapy

Mitral Stenosis

  1. Anticoagulation
  2. Percutaneous mitral balloon valvotomy
  3. Mitral valve repair
  4. Mitral valve replacement
  5. Open commissurotomy

Mitral Valve Prolapse

  1. Aspirin therapy
  2. Warfarin therapy

Mitral Regurgitation

  1. Left ventriculography and hemodynamic measurements
  2. Mitral valve repair
  3. Mitral valve replacement

Tricuspid Regurgitation

Tricuspid valve repair, replacement, or annuloplasty

Pulmonic Stenosis

Intervention in the adolescent or young adult with pulmonic stenosis (balloon valvotomy or surgery)

For the complete guideline, please visit the website.

Guidelines for Percutaneous Coronary Intervention

If you are wondering what the procedure and guidelines are for the percutaneous coronary intervention, the National Guideline Clearinghouse of the U.S. Department of Health and Human Services has provided a thorough summary. Below is a brief excerpt from the guideline:

Target Population

Patients with coronary artery disease

Management/Treatment

  1. Percutaneous coronary interventions (PCI), including percutaneous transluminal coronary angioplasty (PTCA), balloon expandable stents, drug-eluting stents, extraction atherectomy, directional coronary atherectomy, rotational atherectomy, rheolytic thrombectomy catheter, proximal and distal embolic protection devices, excimer laser coronary atherectomy, and local radiation devices to reduce in-stent restenosis
  2. Insurance of institutional and operator competency in performing PCI (quality assurance programs, high-volume operators in high-volume institutions, availability of onsite cardiac surgical back-up or access to cardiac surgical back-up)
  3. Antiplatelet and antithrombotic adjunctive therapies (aspirin, clopidogrel, glycoprotein IIb/IIIa Inhibitors, unfractionated heparin, low-molecular-weight heparin, bivalirudin) in patients undergoing PCI
  4. Special considerations (for example, management of clinical restenosis, ad hoc PCI, PCI in the cardiac transplant patient, and restenosis after stent implantation)
  5. Post-PCI management (postprocedural evaluation of ischemia, risk factor modification, exercise testing, follow-up coronary angiography)

Evaluation/Follow-up

  1. Angiographic assessment
  2. Use of adjunctive technologies
    • Coronary intravascular ultrasound imaging (IVUS)
    • Measurement of coronary flow velocity and coronary vasodilatory reserve
    • Measurement of coronary artery pressure and fractional flow reserve (FFR)
  3. Measurement of creatine kinase-MB isoenzyme and troponins I or T

For a complete guideline, please visit the website here.